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Increases in mRNA levels of glucose transporters types 1 and 3 in Ehrlich ascites tumor cells during tumor development
Author(s) -
Au K.K.,
Liong E.,
Li J.Y.,
Li P.S.,
Liew C.C.,
Kwok T.T.,
Choy Y.M.,
Lee C.Y.,
Fung K.P.
Publication year - 1997
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(19971001)67:1<131::aid-jcb13>3.0.co;2-k
Subject(s) - ehrlich ascites , tumor cells , messenger rna , glucose transporter , transporter , ascites , chemistry , biology , microbiology and biotechnology , biochemistry , endocrinology , cancer research , medicine , gene , insulin
A common feature of many tumors is an increase in glucose catabolism during tumor growth. We studied the mechanism of this phenomenon by using Ehrlich ascites tumor bearing mice as the animal model. We found that Ehrlich ascites tumor cells possess only glucose transporter 1 (GLUT1) and GLUT3 but no GLUT2, GLUT4, or GLUT5. The mRNA levels of GLUT1 and GLUT3 increased progressively in the tumour during development; however, there were no changes observable in mRNA levels of glucose transporters of all types in brain, liver, and heart of the host mice. These findings suggest that Ehrlich ascites tumor augments its glucose transport mechanism relative to other tissues in response to its unique growth needs. J. Cell. Biochem. 67:131–135, 1997. © 1997 Wiley‐Liss, Inc.