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Electromagnetic field exposure induces rapid, transitory heat shock factor activation in human cells
Author(s) -
Lin Hana,
Opler Mark,
Head Mark,
Blank Martin,
Goodman Reba
Publication year - 1997
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(19970915)66:4<482::aid-jcb7>3.0.co;2-h
Subject(s) - hsp70 , heat shock , heat shock protein , microbiology and biotechnology , electromagnetic field , shock (circulatory) , heat shock factor , stimulation , hsf1 , transcription factor , cellular stress response , biophysics , biology , gene , fight or flight response , endocrinology , physics , medicine , biochemistry , quantum mechanics
Stimulation of human promyelocytic HL60 cells by a 60Hz magnetic field at normal growth temperatures results in heat shock factor 1 activation and heat shock element binding, a sequence of events that mediates the stress‐induced transcription of the stress gene HSP70 and increased synthesis of the stress response protein hsp70kD. Thus, the events mediating the electromagnetic field–stimulated stress response appear to be similar to those reported for other physiological stresses (e.g., hyperthermia, heavy metals, oxidative stress) and could well be the general mechanism of interaction of electromagnetic fields with cells. J. Cell. Biochem. 66:482–488, 1997. © 1997 Wiley‐Liss, Inc.