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Nitric oxide releasing reagent, S‐nitroso‐N‐acetylpenicillamine, enhances the expression of manganese superoxide dismutase mRNA in rat vascular smooth muscle cells
Author(s) -
Sano Hiroaki,
Hirai Makoto,
Saito Hidehiko,
Nakashima Izumi,
Isobe Kenichi
Publication year - 1996
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/(sici)1097-4644(199607)62:1<50::aid-jcb6>3.0.co;2-0
Subject(s) - vascular smooth muscle , superoxide dismutase , nitric oxide , nitric oxide synthase , chemistry , snap , lipopolysaccharide , dismutase , messenger rna , superoxide , microbiology and biotechnology , biochemistry , biology , endocrinology , enzyme , smooth muscle , computer graphics (images) , computer science , gene
Cultured rat vascular smooth muscle cells (VSMCs) produce nitric oxide (NO) under stimulation by lipopolysaccharide (LPS) and interferon‐γ (IFN‐γ). NO synthase (NOS) and manganese superoxide dismutase (Mn‐SOD) mRNA expressions are simultaneously induced by these stimulants in rat VSMCs. In VSMCs, S‐nitroso‐N‐acetyl penicillamine (SNAP), one of the NO releasing reagents, induces Mn‐SOD mRNA which may protect the VSMCs themselves. This suggests that NO itself may enhance the expression of Mn‐SOD to protect the VSMC themselves against NO radicals in cultured rat VSMCs. © 1996 Wiley‐Liss, Inc.