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Polyurethane membrane prepared via a dry/wet phase inversion method for protein adsorption
Author(s) -
Huang ShihLiang,
Ou ChengFang,
Lai JuinYih
Publication year - 1999
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19991107)74:6<1334::aid-app2>3.0.co;2-#
Subject(s) - phase inversion , polyurethane , adsorption , membrane , materials science , chemical engineering , protein adsorption , polymer chemistry , composite material , polymer science , chemistry , organic chemistry , engineering , biochemistry
Hydroxyl‐terminated polybutadiene (HTPB)‐ and 4,4′‐dicyclohexyl‐methane (H 12 MDI)‐based polyurethanes (PUs) were synthesized by solution polymerization. PU membranes were prepared by a dry/wet phase inversion method. Protein adsorption ratio of fibrinogen to albumin (F/A molar ratio) was measured. Low F/A molar ratio was found on these PUs. It was found that surface composition of these PUs has a subtle effect on F/A adsorption molar ratio. The F/A molar ratio was increased as the increase of hard segment content distributed on the surface. The variation of surface composition of these membranes and the effect on the F/A molar ratio were investigated by the difference in surface energy between nonpolar HTPB soft segment and polar hard segment, concentration, and temperature of coagulation medium, polymer content, and alcohol type. The CO/CC ratio, frequency shift, and difference (Δν) as a measure of polymer homogeneity and the average strength of interpolymer hydrogen bonds were utilized to study the surface composition. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 1334–1340, 1999