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Permselectivity of nonporous polyurethane membranes for immunoisolation. I. The influence of hydrogen bonding
Author(s) -
George Sheela,
Nair Prabha D.
Publication year - 1999
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19990906)73:10<1949::aid-app14>3.0.co;2-a
Subject(s) - permeation , membrane , polypropylene glycol , polyurethane , chemical engineering , polymer chemistry , hydrogen bond , chemistry , toluene diisocyanate , polymer , materials science , chromatography , organic chemistry , molecule , polyethylene glycol , biochemistry , engineering
Nonporous polyurethane membranes were synthesized using toluene 2,4‐diisocyanate (TDI), polypropylene glycol (PPG), or polytetramethylene glycol (PTMG) as polyols and 1,4‐butanediol as chain extender. The percentage of hard segments was varied keeping the NCO/OH ratio constant as 1. 1. The permeation of glucose, albumin, and insulin through these membranes was studied using spectrophotometric assays. The permeation of glucose was found to be dependent on the hard segment content and hydrophobicity of the polyols, whereas insulin permeation was found to vary with the hydrogen bonding and hard segment content. The permeation of albumin was almost negligible in both systems. As the synthesized nonporous polyurethanes allow the transport of the nutrients' glucose and insulin and prevent the transport of albumin with a molecular weight of 60,000 and immunoglobulins with a molecular weight of 150,000, the membranes are proposed as potential encapsulation matrices for the immunoisolation of islet cells. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 73: 1949–1954, 1999