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The synthesis and characterization of new polymerizable pyrimidines: Immobilization of the monomers onto hydrophilic graft copolymeric supports through radiation‐induced copolymerization–grafting
Author(s) -
Pegiadou S.,
Guthrie J. T.,
Gill M. H.
Publication year - 1998
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19981010)70:2<211::aid-app1>3.0.co;2-x
Subject(s) - copolymer , tmpta , pyrimidine , monomer , polymer chemistry , grafting , chemistry , aqueous solution , methacrylate , materials science , acrylate , organic chemistry , polymer , stereochemistry
Polymerizable quaternary allyl‐pyrimidinium salts, that is, 1‐allyl‐4‐ amino‐5‐phenyl‐pyrimidine (IV), 1‐allyl‐4‐acetamido‐5‐phenyl‐pyrimidine (V), 1‐allyl‐5‐hydroxymethylamino‐5‐phenyl‐pyrimidine (VI), and 1‐allyl‐pyrimidine (VIII) bromides, as well as 4‐acrylamido‐5‐phenyl‐pyrimidines II` and IV`, were synthesized and characterized. Three of the activated pyrimidine derivatives, the two acrylamido and one allyl pyrimidine, were immobilized onto (Agar‐ g‐co ‐HEMA)‐X‐TMPTA via graft copolymerization. Each copolymer system, based on 2‐hydroxyethyl methacrylate (HEMA) grafted onto Agar followed by crosslinking with trimethyllopropane triacrylate (TMPTA), was prepared by radiation‐induced copolymerization carried out in the simultaneous mode. The release properties of the immobilized pyrimidines were assessed in various aqueous media over a period of approximately 22 days. © 1998 John Wiley & Sons, Inc. J. Appl. Polym. Sci. 70: 211–218, 1998