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Thermoreversible hydrogels. IV. Effect of some factors on the swelling behavior of N ‐tetrahydrofurfurylacrylamide
Author(s) -
Lee WenFu,
Yeh PaoLi
Publication year - 1998
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19980606)68:10<1597::aid-app8>3.0.co;2-c
Subject(s) - swelling , self healing hydrogels , polymer chemistry , monomer , miscibility , polymerization , materials science , diffusion , chemical engineering , solvent , copolymer , aqueous solution , acryloyl chloride , polymer , chemistry , composite material , organic chemistry , acrylate , thermodynamics , physics , engineering
A thermoreversible hydrogel, poly( N ‐tetrahydrofurfurylacrylamide) [poly‐(NTHFAAm) gel], was prepared from N ‐tetrahydrofurfurylacrylamide, which was synthesized from N ‐tetrahydrofurfurylamine and acryloyl chloride (through acylation), with N,N ′‐methylenebisacrylamide, a crosslinker, in various aqueous solutions. The influences of temperature, gel thickness, and polymerization media on the swelling behaviors in water were investigated. The effect of the gel thickness on the swelling ratio for NTHFAAm gel indicated that the equilibrium swelling time and diffusion coefficient for the thinner gel were faster than those for the thicker gels. The effects of different polymerization media on the gel swelling ratio showed that the larger the solvent molecular size and the poorer the miscibility of the monomer and solvent, the higher the swelling ratio and diffusion coefficient. The drug release profiles in the various gels were also investigated. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 68: 1597–1603, 1998