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Polyether‐segmented nylon hemodialysis membrane. V. Evaluation of blood compatibility of polyether‐segmented nylons
Author(s) -
Mochizuki Akira,
Seita Yukio,
Nakashima Toshio,
Endo Fumiaki,
Yamashita Shuzo
Publication year - 1998
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19980214)67:7<1253::aid-app14>3.0.co;2-2
Subject(s) - ethylene oxide , biocompatibility , materials science , oxide , propylene oxide , polymer chemistry , membrane , polymer , chemical engineering , composite material , chemistry , copolymer , biochemistry , engineering , metallurgy
The biocompatibility of poly(propylene oxide)‐segmented nylon610 (PPO‐Ny610), poly(ethylene oxide)‐segmented nylon610 (PEO‐Ny610), poly(ethylene oxide)‐segmented nylonM10 (PEO‐NyM10), and poly(ethylene oxide)‐segmented nylon69/M10 (PEO‐Ny69/M10) hollow fibers were investigated in terms of the transient leukopenia by the extracorporeal circulation in a rabbit. PPO‐Ny610 and PEO‐Ny610 hollow fibers showed that the minimum leukocyte counts during the circulations were > 80% against the initial count of leukocyte. These results indicate that these polymers have good blood compatibility. In PEO‐NyM10 and PEO‐Ny69/M10, the remarkable decreases of the leukocyte count were observed and the minimum counts were in the range of 45–50%. From the evaluation results of homo nylons (Ny610 and NyM10) hollow fibers, the low blood compatibilities observed in PEO‐NyM10 and PEO‐Ny69/M10 are not attributed to the chemical structure of the nylon blocks. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 67:1253–1257, 1998