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Interaction of nicotine and its pharmaceutical derivatives with acrylamide/itaconic acid hydrogels
Author(s) -
Karadağ Erdener,
Saraydin Dursun,
Güven Olgun
Publication year - 1997
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19971024)66:4<733::aid-app13>3.0.co;2-s
Subject(s) - itaconic acid , self healing hydrogels , swelling , acrylamide , adsorption , chemistry , aqueous solution , nuclear chemistry , polymer chemistry , nicotinamide , chemical engineering , organic chemistry , polymer , copolymer , engineering , enzyme
Acrylamide/itaconic acid hydrogels (AAm/IA) containing different amounts of itaconic acid prepared by irradiating with γ radiation were used in experiments on swelling, diffusion, and interactions of the pharmaceuticals nicotine, nicotinic acid, nicotinamide, and nikethamide. AAm/IA hydrogel containing 60 mg itaconic acid and irradiated at 4.65 kGy has been used for swelling and diffusion studies in water and aqueous solutions of the pharmaceuticals. For this hydrogel, swelling studies indicated that swelling increased with the following order: water > nicotine > nikethamide > nicotinamide > nicotinic acid. Diffusions of water and the pharmaceuticals within hydrogels were found to be non‐Fickian in character. The uptake of the pharmaceuticals to AAm/IA hydrogels was studied by batch adsorption technique at 25°C. In the experiments of the adsorption, C‐type adsorption in Giles's classification system was found. Some binding and thermodynamic parameters for AAm/IA hydrogel‐pharmaceutical systems were calculated by using the Klotz method. The values of adsorption heat, free energy, and entropy of this system were found as negative values. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 733–739, 1997