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Poly (2‐hydroxyethyl methacrylate)‐based hydrogels for slow release of pralidoxime chloride
Author(s) -
Agarwal Seema,
Sumana G.,
Gupta D. C.
Publication year - 1997
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19971010)66:2<267::aid-app7>3.0.co;2-u
Subject(s) - self healing hydrogels , pralidoxime , 2 hydroxyethyl methacrylate , methacrylate , polymer chemistry , materials science , chloride , chemistry , chemical engineering , composite material , copolymer , organic chemistry , polymer , engineering , acetylcholinesterase , enzyme
Pralidoxime chloride (PAM‐Cl)‐loaded poly (2‐hydroxyethyl methacrylate) (PHEMA)‐based hydrogels were prepared by bulk copolymerization of 2‐hydroxyethyl methacrylate (HEMA) with different mol fractions (0.02–0.10) of trimethylsilyl methacrylate. Characterization of the gels was done by dynamic swelling measurements. It was found that copolymerization does not alter the swelling mechanism of PHEMA and it essentially remains Fickian in nature. In vitro drug‐release studies show the increase in release time from 6 to 12 h on incorporation of a 0.1 mol fraction of trimethylsilyl methacrylate on the PHEMA backbone. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 267–270, 1997