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On the restriction of the release of water‐soluble component from polyvinyl alcohol film by blending β‐cyclodextrin
Author(s) -
Sreenivasan K.
Publication year - 1997
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19970829)65:9<1829::aid-app20>3.0.co;2-g
Subject(s) - polyvinyl alcohol , cyclodextrin , vinyl alcohol , alcohol , polymer chemistry , chemistry , drug , matrix (chemical analysis) , chemical engineering , materials science , organic chemistry , chromatography , polymer , pharmacology , engineering , medicine
The effect of adding β‐Cyclodextrin with poly(vinyl alcohol) (PVA) hydrogel on the release of a water‐soluble component has been investigated. It is found that the release of a model drug, salicyclic acid, from PVA matrix in the presence of β‐cyclodextrin prolonged considerably the release of the profile of the drug from the PVA gel. The profound influence of β‐cyclodextrin on the drug release has been assigned to the ability of β‐cyclodextrin to form an inclusion complex with salicyclic acid. © 1997 John Wiley & Sons, Inc. J Appl Polm Sci 65:1829–1832, 1997