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Polyether‐segmented nylon hemodialysis membranes. III. Preparation and properties of new polyether‐segmented nylon
Author(s) -
Mochizuki Akira,
Seita Yukio,
Azaki T. Nak,
Fukuoka T.,
Matsushima K.,
Yamashita Shuzo
Publication year - 1997
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19970829)65:9<1723::aid-app8>3.0.co;2-h
Subject(s) - copolymer , polymer chemistry , materials science , solubility , ethylene oxide , membrane , polymer , sebacic acid , adhesion , hexamethylenediamine , condensation polymer , chemical engineering , chemistry , polyamide , organic chemistry , composite material , biochemistry , engineering
In order to apply a blood‐compatible polymer to hemodialysis membrane, a new polyether‐segmented nylon which dissolved in common organic solvents was designed. The basic polyether‐segmented nylon was synthesized by melt polycondensation from sebacic acid, m ‐xylenediamine, and α,ω‐bisaminopropyl‐poly(ethylene oxide). To improve the solubility, azelaic acid and hexamethylenediamine were copolycondensed with the basic copolymer. The solubility was correlated with the heat of fusion (Δ H m ) of the copolymer. When Δ H m is < 30 mJ/mg, the polymer is soluble in dimethylsulfoxide and makes a stable solution. The nonthrombogenicity was investigated in the viewpoint of adhesion of platelet onto the copolymer surface. It is made clear that the surface of the block copolymer, having > 10 wt % of poly(ethylene oxide), suppresses the adhesion of platelet, and the composition of the nylon block has no effect on the adhesion of platelet. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 65:1723–1729, 1997