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Synthesis and in vitro degradation of copolymers of glycolide and 6 ( R,S )‐methylmorpholine‐2,5‐dione
Author(s) -
Du Fusheng,
Ye Weiping,
Gu Zhongwei,
Yang Jiyuan
Publication year - 1997
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19970131)63:5<643::aid-app12>3.0.co;2-v
Subject(s) - copolymer , crystallinity , distilled water , degradation (telecommunications) , polymer chemistry , glass transition , nuclear chemistry , materials science , enthalpy of fusion , chemistry , chemical engineering , amorphous solid , melting point , polymer , organic chemistry , chromatography , composite material , telecommunications , computer science , engineering
Copolymerization of glycolide (GA) and 6( R,S )‐methylmorpholine‐2,5‐dione (MMD) was carried out in bulk using stannous octoate as an initiator. The effects of temperature, time, concentration of stannous octoate, and the feed composition on the copolymerization were investigated. DSC analysis showed that glass transition temperature ( T g ) of the resulting copolymers (PGM) increased with increase of MMD content in the copolymers, while melting temperature ( T m ) and heat of fusion (Δ H ) decreased. In vitro degradation was performed in two media: PBS buffer (pH 7.4) and distilled water (pH 6.8). It showed that the erosion rates increased with increasing MMD content in the original copolymers, and the degradation proceeded more rapidly in PBS buffer than in distilled water. Based on the changes of composition and crystallinity of the samples during the degradation, it is suggested that the degradation proceeded through two main stages: first, mainly in amorphous regions and then in crystalline ones. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 63: 643–650, 1997