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Structure of a complex of iron(III) with a crosslinked copolymer of 1‐(β‐acrylamidoethyl)‐3‐hydroxy‐2‐methyl‐4(1H)‐pyridinone and N , N ‐dimethylacrylamide
Author(s) -
Feng Minhua,
van Der Does Leen,
Bantjes Adriaan,
van Berkel Petronella M.,
Reedijk Jan
Publication year - 1996
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/(sici)1097-4628(19960418)60:3<477::aid-app22>3.0.co;2-z
Subject(s) - chemical technology , copolymer , chemistry , polymer chemistry , materials science , polymer science , physics , engineering , polymer , organic chemistry , biochemical engineering
Chelation is of great significance in many chemical and biomedical systems such as the isolation of Fe3+ or A13+, Ga3+ and actinides,'-3 the treatment of iron ~ v e r l o a d , ~ ~ and the inhibition of bacterial Recently, some of us reported the synthesis and properties of several iron(II1) chelating resins with immobilized natural or synthetic iron(II1) chelators." One of these resins (AHMP-DMAA) was prepared by the copolymerization of l-(/3-acrylamidoethyl)-3-hydroxy-2-methyl-4(lH)pyridinone (AHMP) and N,N-dimethylacrylamide (DMAA) in the presence of a crosslinking agent." The structures of the monomer AHMP and of the AHMPDMAA resin are represented in Figure 1. This resin exhibits a high affinity and selectivity for iron(II1) and was found to be chemically stable and reusable. The resin has been used in the removal of iron from iron-binding proteins, milk, wine, or beer," for the inhibition of bacterial growth," and for iron detoxification of poisoned human p1a~ma.I~ Furthermore, the stability constant of its iron(II1) complex was determined recently, and was found to be even higher than that of the corresponding monomer c0mp1ex.I~ Although the AHMP-DMAA resin can be effectively applied for iron(II1) chelation, the structure of the resin-iron(II1) complex so far has been unknown. Iron binding studies with soluble iron(II1) chelating ligands containing the same groups as present in AHMP, showed tha t a ligand/iron(III) ratio of 3 is observed at a p H range of 5-11, with a n octahedral coordination around the iron(II1) i ~ n . ' * ' ~ ' ~ Ho wever, i t is possible tha t differences occur in the coordination mode for the soluble iron(II1) chelate and the resiniron(II1) complex. This article describes the results of a study about the coordination structure using infrared spectroscopy (IR), electron paramagnetic resonance (EPR) , and diffuse reflectance spectroscopy (electron spectroscopy).