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Mechanism of oxidation of diazepam by Chloramine‐B: A kinetic approach
Author(s) -
Nanda N.,
Mayanna S. M.,
Gowda N. M. Made
Publication year - 1998
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/(sici)1097-4601(1998)30:9<605::aid-kin1>3.0.co;2-w
Subject(s) - chemistry , hydrochloric acid , reaction rate constant , kinetic isotope effect , ionic strength , reaction rate , kinetics , kinetic energy , reaction mechanism , aqueous solution , solvent , chloramine t , inorganic chemistry , organic chemistry , catalysis , deuterium , physics , quantum mechanics
The kinetics of the oxidation of diazepam (DZ) by Chloramine‐B (CAB) has been studied in aqueous hydrochloric acid medium. The oxidation reaction follows the rate law: $$\it{-d[\rm{CAB}]\over\it dt_{\ .}}=k\rm{[CAB][DZ]^{0.6}[HCl]^{0.6}}$$ The dependence of the reaction rate on temperature is studied and activation parameters for the rate‐determining step are evaluated. The dielectric constant of the medium has a small effect on the rate. Ionic strength and the reaction product benzenesulfonamide have no effect on the reaction rate. The solvent isotope effect is studied. A probable mechanism for the observed kinetic data is proposed. © 1998 John Wiley & Sons, Inc. Int J Chem Kinet: 30: 605–611, 1998