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Halogenation and amination dual properties of haloamines in Raschig environment: A chlorine transfer reaction between chloramine and 3‐azabicyclo[3,3,0]octane
Author(s) -
Elkhatib M.,
Marchand A.,
Peyrot L.,
Counioux J. J.,
Delalu H.
Publication year - 1997
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/(sici)1097-4601(1997)29:2<89::aid-kin2>3.0.co;2-g
Subject(s) - chemistry , chloramine , amination , chlorine , halogenation , reaction rate constant , order of reaction , protonation , inorganic chemistry , medicinal chemistry , organic chemistry , catalysis , kinetics , ion , physics , quantum mechanics
Abstract The chlorine transfer reaction between 3‐azabicyclo[3,3,0]octane “AZA” and chloramine was studied over pH 8–13 in order to follow both the amination and halogenation properties of NH 2 Cl. The results show the existence of two competitive reactions which lead to the simultaneous formation of N‐amino‐ and N‐chloro‐ 3‐azabicyclo[3,3,0]octane by bimolecular kinetics. The halogenation reaction is reversible and the chlorine derivative obtained, which is thermolabile and unstable in the pure state, was identified by electrospray mass spectrometry. These phenomena were quantified by a reaction between neutral species according to an apparentS N 2‐type mechanism for the amination process and a ionic mechanism involving a reaction between chloramine and protonated amine for the halogenation process. Amination occurs only in strongly basic solutions (pH ≥ 13) while chlorination occurs at lower pH's (pH ≤ 8). At intermediate pH's, a mixture of these two compounds is obtained. The relative proportions of the products are a function of intrinsic rate constants, pH and pK a of the reactants. The rate constants and thermodynamic activation parameters are the following: k 1 = 45.5 × 10 −3 M −1 s −1 ; ΔH 1 0# = 59.8 kJ mol −1 ; ΔS 1 0# = − 86.5 J mol −1 K −1 for amination; k 2 = 114 × 10 −3 M −1 s −1 ; ΔH 2 0# = 63.9 kJ mol −1 ; and ΔS 2 0# = − 48.3 J mol −1 K −1 for chlorination. The ability of an interaction corresponding to a specific (NH 3 Cl + /RR′NH) or general (NH 2 Cl/RR′NH) acid catalysis has been also discussed. © 1997 John Wiley & Sons, Inc.