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Kinetic studies on general base‐catalyzed cleavage of phthalimide (PTH) in 2‐hydroxyethylamine and 2‐methoxyethylamine buffers
Author(s) -
Khan M. Niyaz
Publication year - 1996
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/(sici)1097-4601(1996)28:6<421::aid-kin4>3.0.co;2-x
Subject(s) - chemistry , aminolysis , phthalimide , cleavage (geology) , catalysis , nucleophile , medicinal chemistry , intermolecular force , base (topology) , amine gas treating , stereochemistry , organic chemistry , molecule , mathematical analysis , geotechnical engineering , mathematics , fracture (geology) , engineering
Kinetic studies on the nucleophilic cleavage of phthalimide (PTH) in buffers of 2‐hydroxyethylamine and 2‐methoxyethylamine reveal nonlinear plots of k n vs. [Buf] T (at constant pH) where k n and [Buf] T represent apparent second‐order rate constant and total amine buffer concentration, respectively. The nonlinear variation of k n against [Buf] T is attributed to the occurrence of a stepwise mechanism in the aminolysis of PTH. Intermolecular general base catalysis is detected in the reactions of both amines with nonionized PTH (SH) only within the pH range of the present study. © 1996 John Wiley & Sons, Inc.