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FK506 promotes functional recovery in crushed rat sciatic nerve
Author(s) -
Lee Michelle,
Doolabh Vaishali B.,
Mackin Susan E.,
Jost Sarah
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(200004)23:4<633::aid-mus24>3.0.co;2-q
Subject(s) - medicine , anesthesia , denervation , sciatic nerve , atrophy , hindlimb , muscle atrophy , nerve injury , reinnervation , crush injury , surgery , sciatic nerve injury , limiting , anatomy , mechanical engineering , engineering
In this study we examine whether the systemic administration of FK506 or Cyclosporin A (CsA) expedited functional recovery following an axonotmetic nerve injury, and compared their effects in a rat model. Seventy‐five adult Buffalo rats received a crush injury to the right posterior tibial nerve and subsequently underwent either no treatment (group I), daily injections of FK506 (group II), or daily injections of CsA (group III). Walking track analysis demonstrated return of hindlimb function by 20 days postoperatively in group I, 14 days in group II, and 18 days in group III. The blood–nerve barrier (BNB) was reconstituted by postoperative day (POD) 7 in both FK506‐ and CsA‐treated animals and by POD 13 in control animals. These results suggest that recovery of function is more rapid with daily administration of FK506 than with CsA or no treatment, perhaps because of earlier restoration of the blood–nerve barrier. Agents that facilitate nerve regeneration have the potential to limit the extent of motor endplate loss and muscle atrophy seen with prolonged denervation, thereby limiting permanent functional loss. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 633–640, 2000.