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Benign prognosis in idiopathic hyper‐CK‐emia
Author(s) -
Reijneveld Jaap C.,
Notermans Nicolette C.,
Linssen Wim H.J.P.,
Wokke John H.J.
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(200004)23:4<575::aid-mus17>3.0.co;2-5
Subject(s) - medicine , myalgia , muscle biopsy , electromyography , polyneuropathy , biopsy , neurology , physical examination , surgery , physical therapy , physical medicine and rehabilitation , psychiatry
Abstract We report on the long‐term follow‐up in 31 patients with idiopathic hyper‐CK‐emia. At referral, all patients underwent a neurological interview and examination. Ancillary investigations included an open muscle biopsy and electromyography (EMG) in almost all, and other ancillary tests in some patients. After a follow‐up period of 7.2 (mean; range 4–18) years, 74% of the patients had a final evaluation. The most common complaints at referral were fatigue and myalgia. EMG and muscle biopsy demonstrated minor, non‐diagnostic abnormalities in 30 and 71% of patients, respectively. At follow‐up, the pattern and the number of complaints had not changed substantially. One patient developed a sensory polyneuropathy. Neurological abnormalities were absent in all other patients. In conclusion, long‐term follow‐up of patients with idiopathic hyper‐CK‐emia does not reveal clinical deterioration. It seems justifiable to refrain from routine long‐term follow‐up in these patients. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 575–579, 2000.