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Kaposi's sarcoma herpesvirus–associated Castleman's disease with POEMS syndrome
Author(s) -
Kim DongEog,
Kim Ho Jin,
Kim Young A.,
Lee KwangWoo
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(200003)23:3<436::aid-mus18>3.0.co;2-i
Subject(s) - poems syndrome , organomegaly , castleman disease , polyneuropathy , medicine , pathology , disease , sarcoma , systemic disease , dermatology , immunology
The pathogenic link between POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes, and various other clinical signs) syndrome and Castleman's disease is unclear. Roles for M protein in POEMS syndrome and cytokines in systemic manifestations of multicentric Castleman's disease have been suggested. Recently, pathogenic roles of cytokines in POEMS syndrome and Kaposi's sarcoma–associated herpesvirus (KSHV) in Castleman's disease have been reported. We report on a patient with KSHV‐associated Castleman's disease with POEMS syndrome, and suggest a possible role of KSHV in initiating and linking these two diseases. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 436–439, 2000