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Serum type IV collagen increases with duration of amyotrophic lateral sclerosis
Author(s) -
Houi Kouji,
Kobayashi Takaaki,
Kato Shuichi,
Mochio Soichiro,
Inoue Kiyoharu
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(200003)23:3<430::aid-mus16>3.0.co;2-u
Subject(s) - amyotrophic lateral sclerosis , basement membrane , medicine , type iv collagen , endocrinology , degenerative disease , chemistry , pathology , disease , extracellular matrix , biochemistry , laminin
We analyzed the serum levels of type IV collagen, a major component of the basement membrane, during various stages of sporadic amyotrophic lateral sclerosis (ALS). Serum concentrations of type IV collagen increased significantly with the duration of illness. Findings indicate that the metabolism of type IV collagen and the basement membrane may be affected in the disease process of ALS. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 430–432, 2000