Premium
Muscle phosphorus magnetic resonance spectroscopy oxidative indices correlate with physical activity
Author(s) -
Tartaglia M. Carmela,
Chen Jacqueline T.,
Caramanos Zografos,
Taivassalo Tanja,
Arnold Douglas L.,
Argov Zohar
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(200002)23:2<175::aid-mus5>3.0.co;2-r
Subject(s) - phosphocreatine , deconditioning , oxidative phosphorylation , medicine , chemistry , endocrinology , oxidative metabolism , skeletal muscle , phosphomonoesters , nuclear magnetic resonance spectroscopy , phosphorus , nuclear magnetic resonance , metabolism , energy metabolism , biochemistry , physics , organic chemistry
The purpose of this study was to assess the effect of physical deconditioning on skeletal muscle's oxidative metabolism as evaluated by phosphorus‐31 magnetic resonance spectroscopy ( 31 P MRS). Twenty‐seven subjects without muscle disease, representing a wide range of fitness levels, were evaluated with 31 P MRS. Spectra were obtained at rest and during recovery from in‐magnet exercise. The data show a significant correlation between maximum resting metabolic equivalent (MET) score and the following 31 P MRS recovery indices: adenosine diphosphate and phosphocreatine recovery half‐time; initial phosphocreatine resynthesis rate; calculated estimation of mitochondrial capacity; pH at end of exercise; and phosphocreatine depletion. In addition, significant differences between the deconditioned and conditioned group were found for all of the aforementioned recovery indices. At rest, only the inorganic phosphate concentration was significantly different between the two groups. These data indicate that physical activity level should be taken into account when assessing patients' oxidative metabolism with 31 P MRS. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 175–181, 2000.