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Muscle fiber type‐specific myofibrillar Ca 2+ ATPase activity after spinal cord injury
Author(s) -
Castro Michael J.,
Apple David F.,
MeltonRogers Sandee,
Dudley Gary A.
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(200001)23:1<119::aid-mus17>3.0.co;2-z
Subject(s) - myofibril , spinal cord injury , spinal cord , fiber type , atpase , medicine , anatomy , chemistry , biology , neuroscience , endocrinology , skeletal muscle , biochemistry , enzyme
Biopsies of the vastus lateralis muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar Ca 2+ adenosine triphosphate activity (qATPase), contributes to greater fatigue in affected muscle of spinal cord injured (SCI) patients. The qATPase activity showed a fiber‐type effect, IIax + IIx > IIa > I. Average fiber qATPase and fiber specific qATPase activities were not different between SCI and able‐bodied controls, nor did they change over time. We suggest greater fatigue in SCI subjects early after injury does not reflect increased energy demand of contraction. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 119–121, 2000