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Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition
Author(s) -
Badalamente Marie A.,
Stracher Alfred
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(200001)23:1<106::aid-mus14>3.0.co;2-d
Subject(s) - duchenne muscular dystrophy , calpain , leupeptin , degeneration (medical) , muscular dystrophy , dystrophin , myocyte , mdx mouse , in vivo , endocrinology , medicine , skeletal muscle , chemistry , biology , pathology , biochemistry , enzyme , genetics , protease
Inhibition of muscle degeneration by the tripeptide calpain inhibitor, leupeptin, was tested in vivo in a dystrophin‐deficient mdx murine model. In a short‐term control study, intramuscular administration of leupeptin for 30 days inhibited muscle degeneration as assessed by histologic analysis. Calpain inhibition could be correlated with retention of myofiber size and our results suggest that this may be a promising treatment modality in human Duchenne muscular dystrophy. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 106–111, 2000