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High expression of MHC I in the tibialis anterior muscle of a paraplegic patient
Author(s) -
Hartkopp Andreas,
Andersen Jesper L.,
Harridge Stephen D.R.,
Crone Clarissa,
GruschyKnudsen Tom,
Kjær Michael,
Masao Mizuno,
Ratkevicius Aivaras,
Quistorff Bjørn,
Zhou Shi,
BieringSørensen Fin
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199912)22:12<1731::aid-mus20>3.0.co;2-c
Subject(s) - medicine , tibialis anterior muscle , myosin , spinal cord , skeletal muscle , muscle contraction , anatomy , contraction (grammar) , phosphocreatine , vastus lateralis muscle , leg muscle , electromyography , physical medicine and rehabilitation , chemistry , psychiatry , energy metabolism , biochemistry
A long‐term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1731–1737, 1999