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Clinicopathological study of an autopsy case with sensory‐dominant polyradiculoneuropathy with antiganglioside antibodies
Author(s) -
Obi Tomokazu,
Murakami Toshikazu,
Takatsu Masami,
Kusunoki Susumu,
Serizawa Masahiro,
Mizoguchi Kouichi,
Koike Reiko,
Nishimura Yoshiro
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199910)22:10<1426::aid-mus13>3.0.co;2-h
Subject(s) - sural nerve , sensory system , polyradiculoneuropathy , anatomy , autopsy , sensory nerve , myelin , nerve conduction velocity , nerve root , pathology , dorsum , medicine , axonal degeneration , spinal cord , polyneuropathy , pathological , neuroscience , central nervous system , biology , guillain barre syndrome , immunology
A previously reported patient presenting sensory‐dominant neuropathy with antiganglioside antibodies, bound preferentially to polysi‐ alogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had undergone significant damage. These pathological findings were well correlated with the electrophysiological results showing decreased F‐wave conduction velocities and conduction blocks in motor nerves and decreased or absent sensory action potentials in sensory nerves, with distribution of GD1b in nerve tissues such as dorsal root ganglia and paranodal myelin in the ventral and dorsal roots. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1426–1431, 1999