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Desmin phosphorylation abnormalities in cytoplasmic body and desmin‐related myopathies
Author(s) -
Caron Anne,
Chapon Françoise
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199908)22:8<1122::aid-mus17>3.0.co;2-t
Subject(s) - desmin , myopathy , gene isoform , hyperphosphorylation , pathology , biology , phosphorylation , chemistry , microbiology and biotechnology , biochemistry , medicine , immunohistochemistry , vimentin , gene
Cytoplasmic body myopathy (CBM) and desmin‐related myopathy (DRM) are both characterized by an abnormal accumulation of desmin. To determine whether these abnormalities involve similar or different forms of desmin, we performed desmin two‐dimensional electrophoresis: our results showed an increase in the two acidic isoforms in CBM muscles as compared with an increase in the number of acidic isovariants in DRM samples. A process of hyperphosphorylation involved in these acidic forms was confirmed by alkaline phosphatase application onto the muscle samples in both pathological conditions. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1122–1125, 1999