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Influence of handling procedures on rat plasma creatine kinase activity
Author(s) -
Yerroum Mohammed,
Braconnier François,
Chariot Patrick
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199908)22:8<1119::aid-mus16>3.0.co;2-s
Subject(s) - creatine kinase , medicine , endocrinology , chemistry
Ten‐week‐old Sprague–Dawley rats were held behind the front legs before and during anesthetic injection of sodium pentobarbital (group 1, 12 rats), or lifted by the base of the tail before and during injection (group 2, 12 rats). Creatine kinase (CK) values were higher ( P = 0.004) in group 1 (median 564 IU/L) than in group 2 (median 272 IU/L). Handling rats by holding them behind the front legs may reduce the usefulness of CK activity as a measure of muscular disorders. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1119–1121, 1999