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Dystrophin and utrophin do not play crucial roles in nonmuscle tissues in mice
Author(s) -
Rafael Jill A.,
Trickett Jeffrey I.,
Potter Allyson C.,
Davies Kay E.
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199904)22:4<517::aid-mus14>3.0.co;2-6
Subject(s) - dystrophin , utrophin , duchenne muscular dystrophy , gene isoform , muscular dystrophy , biology , skeletal muscle , microbiology and biotechnology , neuroscience , endocrinology , genetics , gene
The loss of full‐length dystrophin from skeletal muscle leads to the clinical features of Duchenne muscular dystrophy. Both Dp71, a C‐terminal dystrophin isoform, and the dystrophin‐related protein, utrophin, are present at high levels in many nonmuscle tissues. To investigate the roles of these proteins in nonmuscle tissues, mice were generated null for utrophin, and deficient in all dystrophin isoforms. These mice reach adulthood and do not appear to have any devastating pathology in nonmuscle tissues. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 517–519, 1999.