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Steroid‐responsive multifocal demyelinating neuropathy with central involvement
Author(s) -
Liguori Rocco,
Rizzi Romana,
Vetrugno Roberto,
Salvi Fabrizio,
Lugaresi Alessandra,
Cevoli Sabina,
Montagna Pasquale
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199902)22:2<262::aid-mus16>3.0.co;2-1
Subject(s) - medicine , multifocal motor neuropathy , neuroscience , psychology , mismatch negativity , electroencephalography
We describe 2 patients with associated central and peripheral demyelination. Electrophysiological studies revealed a demyelinating polyneuropathy with sensory and motor conduction blocks. Visual evoked potentials were abnormal. Motor evoked potentials showed abnormal central conduction time in 1 patient. Magnetic resonance imaging revealed regions of abnormal high signal in the spinal cord and brain; sural nerve biopsy disclosed a demyelinating neuropathy. Both patients showed clinical and electrophysiological improvement after steroid therapy. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 262–265, 1999