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Absence of transcallosal inhibition in adolescents with diplegic cerebral palsy
Author(s) -
Heinen Florian,
Kirschner Janbernd,
Fietzek Urban,
Glocker FranzXaver,
Mall Volker,
Korinthenberg Rudolf
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199902)22:2<255::aid-mus14>3.0.co;2-7
Subject(s) - transcranial magnetic stimulation , cerebral palsy , hereditary spastic paraplegia , spastic , physical medicine and rehabilitation , pathophysiology , paraplegia , motor cortex , medicine , psychology , neuroscience , stimulation , chemistry , spinal cord , biochemistry , gene , phenotype
The role of intracortical organization in the pathophysiology of cerebral palsy (CP) is not clear. We used transcranial magnetic stimulation to investigate the paradigm of transcallosal inhibition (TI) in a group of adolescent patients with diplegic CP ( n = 4), hereditary spastic paraplegia ( n = 2), and healthy control adolescents ( n = 4). None of the patients with CP showed TI, whereas all other subjects had normal TI. These findings indicate a lack of inhibitory control of the motor cortex in CP. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 255–257, 1999