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Positive sharp wave and fibrillation potential modeling
Author(s) -
Dumitru Daniel,
King John C.,
Rogers William E.,
Stegeman Dick F.
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199902)22:2<242::aid-mus12>3.0.co;2-j
Subject(s) - membrane potential , compound muscle action potential , biophysics , concentric , fiber , fibrillation , muscle fibre , resting potential , electric potential , anatomy , mechanics , electrophysiology , chemistry , physics , neuroscience , skeletal muscle , biology , voltage , medicine , mathematics , atrial fibrillation , geometry , organic chemistry , quantum mechanics
A finite muscle fiber simulation program which calculates the extracellular potential for any given intracellular action potential (IAP) was used to model a fibrillation potential and a positive sharp wave. This computer model employs the core conductor model assumptions for an active muscle fiber and allows two distinct types of end effects: a cut or a crush. A “cut end” is defined as a membrane segment with the termination of both active and passive ion channels. The “crush end” is simulated as a focal membrane segment which blocks action potential propagation, and is connected to a region of normal membrane on either side of it so that a normal transmembrane potential is maintained beyond the crush zone. A prototypical positive sharp wave of appropriate amplitude and duration could only be detected extracellularly by using an IAP of the configuration found in denervated rat muscle recorded from a muscle fiber terminating in a crush segment of membrane. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 242–251, 1999