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P/Q‐type voltage‐gated calcium channel antibodies in paraneoplastic disorders of the central nervous system
Author(s) -
Voltz Raymond,
Carpentier Antoine F.,
Rosenfeld Myrna R.,
Posner Jerome B.,
Dalmau Josep
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199901)22:1<119::aid-mus19>3.0.co;2-5
Subject(s) - medicine , lambert eaton myasthenic syndrome , antibody , paraneoplastic cerebellar degeneration , encephalomyelitis , central nervous system , pathology , cancer , immunology , autoantibody
Whether P/Q‐type voltage‐gated calcium channel (VGCC) antibodies are present in the serum of patients with paraneoplastic syndromes other than the Lambert–Eaton myasthenic syndrome (LEMS) and tumors other than small‐cell lung cancer (SCLC) is controversial. Using a commercially available radioimmunoprecipitation assay kit, we examined the sera of 93 patients with paraneoplastic syndromes of the central nervous system (CNS), including 27 patients with paraneoplastic cerebellar degeneration (PCD) associated with tumors other than SCLC and 66 SCLC patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/SN). All PCD sera from patients with tumors other than SCLC were negative for P/Q‐type VGCC antibodies. Eight of 66 (12%) SCLC patients with PEM/SN had P/Q‐type VGCC antibodies; 4 had LEMS and the other 4 had no symptoms of LEMS or they were overlooked and, therefore, not examined electrophysiologically. In patients with paraneoplastic syndromes of the CNS, the detection of P/Q‐type VGCC antibodies supports the diagnosis of LEMS; in our series, only 6% of patients with SCLC and PEM/SN may have had a false positive antibody result, or undiagnosed LEMS. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 119–122, 1999