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Immune‐mediated peripheral neuropathies and voltage‐gated sodiums channels
Author(s) -
Benatar Michael,
Willison Hugh J.,
Vincent Angela
Publication year - 1999
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199901)22:1<108::aid-mus16>3.0.co;2-i
Subject(s) - sodium channel , tetrodotoxin , neuroscience , ganglioside , guillain barre syndrome , immune system , electrophysiology , medicine , peripheral neuropathy , chemistry , biology , immunology , endocrinology , sodium , biochemistry , organic chemistry , diabetes mellitus
Antibodies to GM 1 ganglioside are found in some patients with the Guillain–Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage‐gated sodium channel (VGSC) function by 22 Na + influx in a motor neuronal cell line (NSC19) in which we demonstrated GM 1 ganglioside and tetrodotoxin‐sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 108–110, 1999