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Selective degeneration of sudomotor fibers in Ross syndrome and successful treatment of compensatory hyperhidrosis with botulinum toxin
Author(s) -
Bergmann Ilka,
Dauphin Michel,
Naumann Markus,
Flachenecker Peter,
Müllges Wolfgang,
Koltzenburg Martin,
Sommer Claudia
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199812)21:12<1790::aid-mus26>3.0.co;2-i
Subject(s) - sudomotor , hyperhidrosis , botulinum toxin , medicine , skin biopsy , dermatology , surgery , anatomy , pathology , biopsy
We report a 5‐year follow‐up of a patient with Ross syndrome. A biopsy of the anhidrotic skin immunostained with protein gene product 9.5 visualized by confocal microscopy revealed selective loss of sudomotor fibers, whereas epidermal innervation remained intact, providing the first morphologic evidence of selective loss of sudomotor fibers in this syndrome. Among the different treatment strategies employed for the patient's disabling segmental hyperhidrosis, intracutaneous injection of botulinum toxin A was the most helpful. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1790–1793, 1998