Premium
Ectopic impulse generation and autoexcitation in single myelinated afferent fibers in patients with peripheral neuropathy and positive sensory symptoms
Author(s) -
Campero Mario,
Serra Jordi,
Marchettini Paolo,
Ochoa José L.
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199812)21:12<1661::aid-mus6>3.0.co;2-n
Subject(s) - medicine , peripheral , peripheral neuropathy , pathophysiology , sensory system , stimulus (psychology) , stimulation , receptive field , neuroscience , pathology , endocrinology , biology , psychology , psychotherapist , diabetes mellitus
Microneurographic studies were performed using cutaneous nerves of 8 patients with documented peripheral neuropathy who expressed positive sensory symptoms. Intraneural recordings in single myelinated fibers revealed: (i) ectopic generation of bursts of spontaneous action potentials; (ii) ectopic generation of ongoing repetitive discharges transiently interrupted by natural stimulation of the receptive field; and (iii) repetitive discharges triggered by a preceding action potential. These results provide direct evidence of a peripheral pathophysiological basis for spontaneous and stimulus‐induced paresthesias and dysesthesias in patients with peripheral neuropathy. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1661–1667, 1998