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Intrasphincteric injection of botulinum toxin is effective in long‐term treatment of esophageal achalasia
Author(s) -
Annese Vito,
Basciani Mario,
Borrelli Osvaldo,
Leandro Gioacchino,
Simone Pasquale,
Andriulli Angelo
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199811)21:11<1540::aid-mus27>3.0.co;2-2
Subject(s) - achalasia , botulinum toxin , medicine , toxin , surgery , anesthesia , esophagus , gastroenterology , chemistry , biochemistry
We investigated the long‐term efficacy and safety of intrasphincteric injections of botulinum toxin (100 U) in 57 patients with esophageal achalasia. One month after treatment, 50 patients had improved (88%); both symptom score and LES pressure were significantly reduced ( P < 0.001). After a mean follow‐up of 24 ± 15 months (range 6–48), 43 patients (75%) are still in remission, although repeat injections of toxin were needed to achieve a stable effect on symptoms. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1540–1542, 1998