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Sodium withdrawal contractures in developing and regenerating rat extensor digitorum longus muscles
Author(s) -
Louboutin JeanPierre,
Noireaud Jacques
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199811)21:11<1530::aid-mus24>3.0.co;2-2
Subject(s) - muscle contracture , sarcolemma , denervation , autotransplantation , extensor digitorum longus muscle , contracture , anatomy , medicine , anesthesia , chemistry , surgery , skeletal muscle , transplantation
During postnatal development of extensor digitorum longus (EDL) muscle, sodium withdrawal contractures were observed during the first 6 days after birth, and not after this time. In regenerating EDL muscles, zero‐Na contractures were demonstrated: (1) 7 days after bupivacaine injection, but not 14 or 90 days after this injection; (2) 7, 14, and 90 days after autotransplantation; and (3) 7, 14, and 90 days after the intervention in sliced muscles. The present findings emphasize the role of the denervation in the development of zero‐Na contractures in the regenerating muscles and suggest that a calcium–sodium exchange across the sarcolemma may appear in these muscles. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1530–1532, 1998