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Conduction velocity versus amplitude analysis: Evidence for demyelination in diabetic neuropathy
Author(s) -
Wilson John R.,
Stittsworth James D.,
Kadir Abdul,
Fisher Morris A.
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199809)21:9<1228::aid-mus20>3.0.co;2-m
Subject(s) - nerve conduction velocity , medicine , diabetic neuropathy , compound muscle action potential , amyotrophic lateral sclerosis , chronic inflammatory demyelinating polyneuropathy , diabetes mellitus , cardiology , polyneuropathy , tibial nerve , electromyography , axon , electrophysiology , anatomy , endocrinology , physical medicine and rehabilitation , antibody , disease , stimulation , immunology
Motor conduction velocities (CVs) were correlated with distal compound muscle action potential (CMAP) amplitudes for tibial, peroneal, and median nerves in patients with biopsy‐proven chronic inflammatory demyelinating polyneuropathy (CIDP), diabetic neuropathy, and amyotrophic lateral sclerosis. Only in the diabetic patients did CV significantly correlate with CMAP amplitude. The data show that diabetic neuropathy produces conduction velocity slowing that cannot be explained by axon loss alone, and that differentiation between diabetic neuropathy and CIDP in an individual nerve is difficult. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1228–1230, 1998.