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The effect of age and temperature on MDX muscle fatigue
Author(s) -
Wineinger Mark A.,
Walsh Sandra A.,
Abresch Richard T.
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199808)21:8<1075::aid-mus14>3.0.co;2-t
Subject(s) - muscle fatigue , physical medicine and rehabilitation , medicine , physical therapy , electromyography
We have studied the in vitro contractile and fatigue characteristics of extensor digitorum longus (EDL) muscles from 8‐ and 62‐week‐old dystrophin‐deficient ( mdx ) and control mice at 20°C and 35°C. There were no differences in fatigability at 20°C, but at 35°C the dystrophin‐deficient muscles demonstrated increased fatigability compared to controls, with the older mice exhibiting the greatest fatigue. These results suggest a temperature‐related mechanism of myofibrillar fatigue in dystrophin‐deficient EDL muscles. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:1075–1077, 1998.