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Macrophage apoptosis in muscle tissue in experimental autoimmune myasthenia gravis
Author(s) -
Shi FuDong,
Bai XueFeng,
Li HuLun,
Link Hans
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199808)21:8<1071::aid-mus13>3.0.co;2-x
Subject(s) - myasthenia gravis , apoptosis , macrophage , pathology , autoimmune disease , immunology , medicine , biology , antibody , biochemistry , in vitro
Combining in situ tailing and immunocytochemical staining, we demonstrated that the infiltrating macrophages in muscle tissue sections during early phase of experimental autoimmune myasthenia gravis (EAMG) in Lewis rats were eliminated by apoptosis at high frequency. These apoptotic macrophages were colocalized in the end‐plate regions. Apopto‐sis is a major cause for elimination of infiltrating macrophages during the early phase of EAMG. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:1071–1074, 1998.