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Longitudinal study of skeletal muscle adaptations during immobilization and rehabilitation
Author(s) -
Vandenborne Krista,
Elliott Mark A.,
Walter Glenn A.,
Abdus Sadi,
Okereke Enyi,
Shaffer Michael,
Tahernia David,
Esterhai John L.
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199808)21:8<1006::aid-mus4>3.0.co;2-c
Subject(s) - isometric exercise , ankle , medicine , muscle atrophy , magnetic resonance imaging , skeletal muscle , physical medicine and rehabilitation , atrophy , rehabilitation , physical therapy , anatomy , radiology
This study describes the metabolic, morphologic, neurologic, and functional adaptations observed in the plantar flexors during 8 weeks of lower leg immobilization and 10 weeks of physical therapy following ankle surgery. A combination of magnetic resonance imaging and spectroscopy, isokinetic and isometric muscle testing, and simple functional tests revealed many adaptive changes due to immobilization, including atrophy, loss of muscle strength, reduced central activation, increase in fatigue resistance, and an increase in inorganic phosphate content. After 10 weeks of physical therapy all alterations were reversed, with the exception of a remaining 5.5% deficit in total muscle cross‐sectional area. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:1006–1012, 1998.