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Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies
Author(s) -
Khwaja Shamsuddin,
Sripathi Naganand,
Ahmad B.K.,
Len Vanda A.
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199807)21:7<943::aid-mus14>3.0.co;2-r
Subject(s) - motor neuron , lower motor neuron , medicine , paraneoplastic cerebellar degeneration , upper motor neuron , electromyography , pathology , antibody , neuron , proximal muscle weakness , disease , weakness , neuromuscular disease , autoantibody , neuroscience , amyotrophic lateral sclerosis , immunology , anatomy , biology , physical medicine and rehabilitation , biopsy , muscle biopsy , psychiatry
Autoimmune serological testing is a useful aid for identifying a paraneoplastic basis for sporadic motor neuron disease. A 67‐year‐old woman with ovarian carcinoma presented with progressive weakness. Neurological examination was suggestive of motor neuron disease with signs of upper motor neuron disorder. Electromyography revealed severe motor neuronopathy of the upper extremities. Characteristic type 1 Purkinje cell antibodies (anti‐Yo antibody) was detected in the serum diluted at 1:61,400. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:943–945, 1998.