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Abnormalities of cardiac repolarization in multiple sclerosis: Relationship with a model of allergic encephalomyelitis in rat
Author(s) -
Drouin Emmanuel,
Nataf Serge,
Lande Gilles,
Louboutin JeanPierre
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199807)21:7<940::aid-mus13>3.0.co;2-u
Subject(s) - medicine , multiple sclerosis , encephalomyelitis , repolarization , qt interval , cardiology , sudden cardiac death , anesthesia , electrophysiology , immunology
Ventricular repolarization was investigated for the first time in 48 multiple sclerosis (MS) patients using measurement of QTc interval on standard electrocardiographic recordings. The repolarization process was prolonged significantly in MS compared to control subjects ( P = 0.0001). This result was confirmed with an animal model of MS, i.e., the experimental allergic encephalomyelitis in rat. The contribution of prolonged QT to syncopal attack or sudden cardiac death in MS patients need further investigation. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:940–942, 1998.