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Paraneoplastic demyelinating neuropathy, subacute sensory neuropathy, and anti‐hu antibodies: Clinicopathological study of an autopsy case
Author(s) -
Antoine JeanChristophe,
Mosnier JeanFrançois,
Honnorat Jérôme,
Convers Philippe,
Absi Léna,
Lapras Jérôme,
Michel Daniel
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199807)21:7<850::aid-mus2>3.0.co;2-5
Subject(s) - medicine , pathology , autopsy , peripheral neuropathy , immunohistochemistry , sensory nerve , cd68 , chronic inflammatory demyelinating polyneuropathy , antibody , sensory system , immunology , neuroscience , biology , endocrinology , diabetes mellitus
A patient with anti‐Hu antibodies, small‐cell lung carcinoma, and autopsy‐proven subacute sensory neuropathy had early slowing of motor and sensory conduction velocities. In the peripheral nerves, chronic demyelinating and remyelinating lesions with axonal degeneration were associated with an inflammatory reaction consisting of CD8+ T cells and CD68+ macrophages. On immunohistochemical testing, the patient's serum did not react with normal nerve, suggesting that the Hu proteins were not the target of the inflammatory reaction in the nerve. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:850–857, 1998.