Premium
Force and stiffness of old dystrophic ( mdx ) mouse skeletal muscles
Author(s) -
Bobet Jacques,
Mooney Robert F.,
Gordon Tessa
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199804)21:4<536::aid-mus15>3.0.co;2-v
Subject(s) - duchenne muscular dystrophy , mdx mouse , muscular dystrophy , anatomy , eccentric , medicine , muscle stiffness , dystrophin , stiffness , physics , quantum mechanics , thermodynamics
It has recently been suggested, based on studies of tissue pathology, that the limb muscles of old mdx mice may be a good model for the muscular changes seen in human Duchenne muscular dystrophy. To test this hypothesis, we measured force and stiffness of soleus and extensor digitorum longus (EDL) muscles of old (20–21 months) mdx mice and age‐matched controls. The mdx and control muscles generated similar twitch, tetanic, and eccentric forces. They were also equally stiff. The results show that the mechanics of aged mdx limb muscles differ greatly from Duchenne muscular dystrophy in humans, and disagree with the hypothesis. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:536–539, 1998.