Premium
Transcutaneous access to retrograde axonal flow
Author(s) -
Costas Paul D.,
Sabin Thomas D.,
Wang KaiKai,
Jones David S.,
Seckel Brooke R.
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199804)21:4<531::aid-mus13>3.0.co;2-#
Subject(s) - axoplasmic transport , dorsum , dimethyl sulfoxide , fluorescence , chemistry , tracer , central nervous system , aqueous solution , anatomy , biophysics , medicine , neuroscience , biology , organic chemistry , physics , quantum mechanics , nuclear physics
Transcutaneous entry of fluorescent tracer and subsequent retrograde neuronal transport achieved by the use of dimethyl sulfoxide (DMSO) as a vehicle fluorescent dye dissolved in DMSO and applied topically to the hind limb of rats was found in corresponding dorsal root ganglia; aqueous absorption of tracer dye by neuronal tissue was not demonstrated. This example of transcutaneous access and retrograde transport may have implications as to the entry of various toxins, viruses, chemicals, and therapeutic agents to the nervous system. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:531–532, 1998.