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Agrin and acetylcholine receptor distribution following electrical stimulation
Author(s) -
Stanco Anne M.,
Werle Michael J.
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199803)21:3<407::aid-mus18>3.0.co;2-w
Subject(s) - agrin , reinnervation , neuromuscular junction , stimulation , acetylcholine receptor , basal lamina , neuroscience , acetylcholine , repetitive nerve stimulation , receptor , biology , chemistry , medicine , endocrinology , anatomy , electromyography , ultrastructure
Electrical stimulation is a therapeutic modality available for the preservation of muscle function following peripheral nerve injury. Agrin, a synaptic basal lamina protein, induces accumulation of acetylcholine receptors (AChRs) and other molecules at the neuromuscular junction. Electrical stimulation of denervated muscle does not alter agrin and AChR distribution at abandoned synaptic sites, supporting the hypothesis that the existing aggregation of synaptic molecules, which may be necessary for successful reinnervation, is unaltered by electrical stimulation of denervated muscle. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:407–409, 1998.