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Enzymes of the purine nucleotide cycle in muscle of patients with exercise intolerance
Author(s) -
Operti MariaGrazia,
Vincent M.Françoise,
Brucher JeanMarie,
van den Berghe Georges
Publication year - 1998
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199803)21:3<401::aid-mus16>3.0.co;2-1
Subject(s) - exercise intolerance , amp deaminase , medicine , endocrinology , adenosine deaminase , hyperammonemia , biology , biochemistry , adenosine , heart failure
The activities of adenylosuccinate synthetase, adenylosuccinate lyase, and adenosine monophosphate deaminase were measured in muscle from patients suffering from fatigue and cramps following exercise. Results denote the existence of secundary deficiencies of adenylosuccinate synthetase and/or adenylosuccinate lyase in subjects with congenital or acquired myopathies. They also suggest that searches are warranted for primary deficiencies of adenylosuccinate synthetase as a cause of exercise intolerance. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:401–403, 1998.