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Focal myopathy associated with chronic intramuscular injection of piritramide
Author(s) -
Van den Bergh Peter Y.K.,
Guettat Lamia,
vande Berg Bruno C.,
Martin JeanJacques
Publication year - 1997
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/(sici)1097-4598(199712)20:12<1598::aid-mus18>3.0.co;2-x
Subject(s) - medicine , myopathy , skeletal muscle , anatomy , surgery
We report a patient in whom chronic intramuscular piritramide led to a focal fibrotic myopathy. Since piritramide myotoxicity has never been reported, we have studied its effect on rat skeletal muscle. Chronic intramuscular piritramide led to fibrous connective tissue replacement of rat skeletal muscle, similar to that found in the patient's muscle. Although the pathogenetic mechanism of piritramide myopathy is unclear, we caution against prolonged intramuscular use of piritramide to prevent this potentially debilitating adverse effect. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1598–1600, 1997